Mary Musgrove was the daughter of the English trader Edward Griffin and a Creek Indian mother. She spent most of her childhood living in both worlds of her Creek village, Coweta, and the colony of South Carolina. During these years, she learned to speak the Creek language of Muskogee as well as English. She learned to be a trader with the English and Native American societies. Despite her mixed heritage, Musgrove was a full member of Creek society and the Wind Clan.